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Magnetic Resonance An interactive open-access publication of the Groupement AMPERE
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https://doi.org/10.5194/mr-2020-4
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/mr-2020-4
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.

Submitted as: communication 20 Feb 2020

Submitted as: communication | 20 Feb 2020

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This preprint is currently under review for the journal MR.

Dipolar Order Mediated 1H→13C Cross-Polarization for Dissolution-Dynamic Nuclear Polarization

Stuart J. Elliott1, Samuel F. Cousin1, Quentin Chappuis1, Olivier Cala1, Morgan Ceillier1, Aurélien Bornet2, and Sami Jannin1 Stuart J. Elliott et al.
  • 1Centre de Résonance Magnétique Nucléaire à Très Hauts Champs - FRE 2034 Université de Lyon / CNRS / Université Claude Bernard Lyon 1 / ENS de Lyon, 5 Rue de la Doua, 69100 Villeurbanne, France
  • 2Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédéralede Lausanne (EPFL), Batochime, CH-1015 Lausanne, Switzerland

Abstract. Magnetic resonance imaging and spectroscopy often suffer from a low intrinsic sensitivity, which can in some cases be circumvented by the use of hyperpolarization techniques. Dissolution-dynamic nuclear polarization offers a way of hyperpolarizing 13C spins in small molecules, enhancing their sensitivity by up to four orders of magnitude. This is usually performed by direct 13C polarization, which is straightforward but often takes more than an hour. Alternatively, indirect 1H polarization followed by 1H→13C polarization transfer can be implemented, which is more efficient and faster but is technically very challenging and hardly implemented in practice. Here we propose to remove the main roadblocks of the 1H→13C polarization transfer process by using alternative schemes with: (i) less rf-power; (ii) less overall rf-energy; (iii) simple rf-pulse shapes; and (iv) no synchronized 1H and 13C rf-irradiation. An experimental demonstration of such a simple 1H→13C polarization transfer technique is presented for the case of [1-13C]sodium acetate, and is compared with the most sophisticated cross-polarization schemes. A polarization transfer efficiency of ~ 0.43 with respect to cross-polarization was realized, which resulted in a 13C polarization of ~ 8.7 % after ~ 10 minutes of microwave irradiation and a single polarization transfer step.

Stuart J. Elliott et al.

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Latest update: 02 Apr 2020
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Short summary
A dipolar cross-polarization (dCP) sequence employing simple radiofrequency pulse shapes with reduced power requirements is demonstrated to transfer proton polarization to insensitive heteronuclei.
A dipolar cross-polarization (dCP) sequence employing simple radiofrequency pulse shapes with...
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